IL-6 blocks a discrete early step in lymphopoiesis

IL-6 blocks a discrete early step in lymphopoiesis.

Animals lacking Src homology 2 domain-containing inositol 5-phosphatase (SHIP) display a reduction in lymphopoiesis and a corresponding enhancement of myelopoiesis. These effects are mediated at least in part by elevated levels of interleukin 6 (IL-6). Here, we show the lymphopoiesis block in SHIP-/- mice is due to suppression of the lymphoid lineage choice by uncommitted progenitors. The suppr...

Viral IL-6 blocks neutrophil infiltration during acute inflammation.

Pathologies arising as a consequence of human herpesvirus-8 (HHV8) infections are closely associated with the autocrine activity of a HHV8 encoded IL-6 (vIL-6), which promotes proliferation of infected cells and their resistance to apoptosis. In this present report, studies show that vIL-6 may also be important in influencing the host's immunological response to secondary infections. Using peri...

a step-by-step framework on discrete events simulation in emergency department; a systematic review

objective: to systematically review the current literature of simulation in healthcare including the structured steps in the emergency healthcare sector by proposing a framework for simulation in the emergency department. methods: for the purpose of collecting the data, pubmed and acm databases were used between the years 2003 and 2013. the inclusion criteria were to select english-written arti...

Conserved IL-2Rgc Signaling Mediates Lymphopoiesis in Zebrafish

Conserved IL-2Rγc Signaling Mediates Lymphopoiesis in Zebrafish.

The IL-2 receptor γ common (IL-2Rγc) chain is the shared subunit of the receptors for the IL-2 family of cytokines, which mediate signaling through JAK3 and various downstream pathways to regulate lymphopoiesis. Inactivating mutations in human IL-2Rγc result in SCID, a primary immunodeficiency characterized by greatly reduced numbers of lymphocytes. This study used bioinformatics, expression an...